As to (1), the OPs first article actually does mention several probability measures "to construct" a functioning protein. (See also comments below this answer.) These estimates seem to me rather like back-of-the-envelope guestimates. Moreover, they also completely ignore the recursive evolutionary process in which those proteins might have developed. (If we simply calculate the "probability" of "constructing" Shakespeare's collected plays by considering the space of all random alphabetic sequences (in a given length range), then that probability would also be "vanishingly" small, much smaller than 1 in 1065. It's a miracle they could ever be created at all... In fact, even if we just consider the probability of constructing oneone of Shakespeare's sonnets in terms of a trigram language model build on words, instead of letters, a reasonable guestimate might be 10-240. These kind of numbers, where "information" is just considered as some kind of "given" don't mean much. We have to ask: how did that "given" develop.)
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