You would have to know what Reality is, independently of our concepthistorical concepts of it, to know whether that concept acquaintsthose concepts acquaint us in any way with its nature. But we only have the concepts, verifying which against Reality appears impossible : it would need access to an unconceptualised Reality to ascertain any difference or agreement between our concepts and Reality.
On the other hand, assuming that ourany concept of Reality itself is real, i.e. a genuine and existent mental phenomenon, we might reasonably claim to know that Reality is such as to admit conceptsconceptualisation - accurate or imperfect - of itself.
Btw I think 'concept' should be 'concepts'. There is no single concept of nature, and I'm pretty sure there never has been. Just saying.