Quine's holism is marked by a scientific methodology. Perhaps not all beliefs in Quine's web of belief are accurate, but at its best the web consists of the refined, matured string of beliefs which are collectively of a scientific nature.
However, a natural question arises: just what qualifies as 'scientific' for Quine?
And another question: how is the traditional epistemologist's understanding of knowledge related to Quine's understanding?
A simpler summary of these questions is as follows: what does Quine accept and reject of the traditional conception of 'knowledge' and 'science', and how are the two related in Quine's approach?
And although it might be asking a bit much, what is the role of pragmatism in all this for Quine?