In De Caelo 300b, Aristotle introduces the idea of the random emergence of the natural:
"it is possible that with this disorderly motion some of the elements might have unified in those combinations which constitute natural bodies"
and then he dismisses the idea. But notice that this possibility is the defeater of any theory of everything. Say you had the single mathematical framework and non-arbitrary physical constants that explained everything. It would still suffer two weaknesses. First, there could be unseen further facts that are anomalous to the theory. Second, the mathematical framework and physical constants could be a pattern in an enormous transient of a random sequence. Then, all physics is just pareidolia or apophenia, even though it is manifestly empirically supported. Is this skepticism?