Truth tables can become large if there are many sentence letters That is when natural deduction might find a solution in a more economical manner. That assumes one can derive a line in a natural deduction proof that corresponds to the desired conclusion. If not, one has to keep looking. A truth table, although potentially large, would let one know one does not have to continue.
Here is how the authors of forallx describe the situation in Chapter 20: Soundness and Completeness, page 149:
Now that we know that the truth table method is interchangeable with the method of derivations, you can chose which method
you want to use for any given problem. Students often prefer to
use truth tables, because they can be produced purely mechanically, and that seems ‘easier’. However, we have already seen that
truth tables become impossibly large after just a few sentence letters. On the other hand, there are a couple situations where using
proofs simply isn’t possible. We syntactically defined a contingent
sentence as a sentence that couldn’t be proven to be a tautology
or a contradiction. There is no practical way to prove this kind of
negative statement. We will never know if there isn’t some proof
out there that a statement is a contradiction and we just haven’t
found it yet. We have nothing to do in this situation but resort
to truth tables. Similarly, we can use derivations to prove two
sentences equivalent, but what if we want to prove that they are
not equivalent? We have no way of proving that we will never find
the relevant proof. So we have to fall back on truth tables again.
P. D. Magnus, Tim Button with additions by J. Robert Loftis remixed and revised by Aaron Thomas-Bolduc, Richard Zach, forallx Calgary Remix: An Introduction to Formal Logic, Winter 2018. http://forallx.openlogicproject.org/