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Are there other reasons than "the world is an illusion or a simulation" that the radical skeptics use to doubt almost everything? I don't think there's a better reason than it, but maybe there are other reasons to doubt a lot of things, what are some of them? In my knowledge there aren't other reason, but I might be wrong.

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  • Who exactly are those radical skeptics? If we can't identify who you are referring to we can't discuss their argument. – armand May 30 at 1:45
  • Pyrrho is the stereotype 'radical skeptic', and he did not bother with 'the world is an illusion', he just systematically undermined the assumptions we have about the well-foundedness of our reasons for things. The Eleatics were more of the 'the world is all an illusion' bent, and they were not radical skeptics they followed their chosen foundations into the conclusion that you should not trust reality as do most 'perennial philosophies'. So at least in their oldest forms, you are ascribing things wrong here. Most people who think the world is all illusion do so from a very strong dogma. – hide_in_plain_sight May 30 at 2:40
  • "The world is an illusion or a simulation" is a skeptical claim, it is not a reason for it. Two typical reasons given are "we can't prove or disprove it with certainty" and pessimistic induction. The latter looks at history and surmises that many major claims widely believed in the past (stationary Earth at the center of cosmos, classical mechanics, phlogiston, ether, universal time, determinism, etc.) ended up overthrown by later developments, so why should it be any different with the rest. – Conifold May 30 at 5:42
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Bertrand Russell has a famous quote according to here and here:

The fundamental argument for freedom of opinion is the doubtfulness of all our belief.

The fundamental cause of the trouble is that in the modern world the stupid are cocksure while the intelligent are full of doubt.

So if you don't want to be a radical skeptic, there's at least some philosophers' quote to argue for some skepticism in general. In deductive reasoning like logic and math realms, most common knowledge status quo may be hard to doubt under their corresponding applicable contexts or axiomatic systems. However, in inductive reasoning realm the confirmation of an argumentative conclusion in the form of hypothesis is very susceptible for doubt due to its limited background assumption and knowledge. For example, I. J. Good gives an example of the observation of a black raven actually decreases the probability of the to be confirmed hypothesis "All ravens are black" according to here:

Suppose that we know we are in one or other of two worlds, and the hypothesis, H, under consideration is that all the ravens in our world are black. We know in advance that in one world there are a hundred black ravens, no non-black ravens, and a million other birds; and that in the other world there are a thousand black ravens, one white raven, and a million other birds. A bird is selected equiprobably at random from all the birds in our world. It turns out to be a black raven. This is strong evidence ... that we are in the second world, wherein not all ravens are black...

So even you did some effort and empirically confirmed a hypothesis per your specific limited observations, you cannot claim such confirmation is strong enough or even relevant at all to inductively infer the intended hypothesis in some cases without knowing all other background assumptions, hypotheses and knowledges which may be never knowable as above example exemplifies...

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Famously, Descartes assumed that a claim was false if it "falls prey to even the slightest doubt". He reasoned that if he did this, than any conclusions that he reaches must be undeniably true. Very few people claim that he was incorrect in this idea. Instead, people who reject his philosophy tend to claim that his notion of 'doubt' was not strict enough or that he made errors in his formal logic.

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