Philosophical analysis is not going to tell us which is the solution to this question.
All that analysis ever does is to make conceivable solutions explicit, This produces alternative conclusions the truth of which depends on which premises are true and we don't know that either just by analysis. Analysis is very useful but doesn't say which is the correct possibility.
If reality is not infinitely divisible, we might get close to the "bottom". We are apparently already much closer to the bottom than our unaided sensory perception gets.
If infinity is infinitely divisible, science itself is illusory in that it can only provide a better picture, not even of what the local reality is, but of what it superficially looks like, and then only here and now.
Intuitively, it seems most people go for not infinitely divisible. Yet, even if this is true, it may be much more divisible than we currently think it is. If this is so, then science will keep producing more and more bewildering results. We may end up looking at the division of matter no longer as a quest for pure knowledge than we may believe that it is, but as a sort of necessary journey through the layers of appearances to find with each new layer the ground for perhaps new technological opportunities. But would any sentience have the time and QI to get to the end of this road before the universe folds down one way or this other?
Quantum mechanics seems to suggest a much more simple reality, if simple is the right word. If reality is that simple, the science of it should converge sooner rather than later on a true model of it. Yet, even if it does, we won't know that it will have. We will see that our model works but all that we will be able to infer reasonably is that it has worked all good so far. And analysis won't get us any truer.
More fundamentally, we cannot possibly understand reality. We are only human after all, and we understand reality by explaining something apparently real in terms of something else apparently real. There is by definition nothing else but reality so that there is nothing else we could use to explain reality with. This is what the notion of substance implies. There is nothing to define what it is except itself and so you cannot explain it. Science itself only ever explains one layer of appearances in terms of another layer, hence the idea of an infinite analysis of reality. If there is a last layer, we won't be able to explain it.
Philosophy is all very interesting but we don't spend the money we spend on science to solve philosophical questions. Science is not a quest for knowledge, it is a quest for practical solutions to practical problems. We don't need to know, we just want to survive, and we don't need to know in order to survive. We just need our science to work well enough to help us survive. Science is fundamentally just human rationality, the rationality of everyday life, only done more systematically, more rigorously, with more organisation, with more money, and crucially, with a memory that goes much beyond any human's life span. No wonders that it works and works well, but it is nonetheless not actual knowledge. It is belief which works for what we need.
And so science won't get us to the bottom either. If reality is infinitely divisible, we might get smart enough to do some of the journey and enjoy the show.