Scientific research involves the investigation of difficult problems, and constantly tries to explain the unknown through observations and logical reasoning.
Take a situation like finding a cure for Alzheimer's. Considered the graveyard of pharmaceutical R&D, some brilliant minds have attempted to create a drug that alleviates the disease but to no avail. The most that we currently have are medications that treat symptoms. The most recent attempt, Aduhelm, was quickly pushed through the FDA even though it showed lackluster results. Society may or may not see a cure.
Whenever a potential solution fails, a scientist would say that more research needs to be done as there might be a mysterious factor that plays a critical role in disease pathology.
**Is there a time when it is no longer rational to seek an explanation given current conditions? Are the explanations that are inherently beyond human powers of investigation? Are there brute facts that simply have no explanation? **