Substance {Gk. ουσια [ousia]; Lat. substantia}
"What a thing is made of; hence, the underlying being that supports, exists independently of, and persists through time despite changes in, its accidental features."
Can we say that there is any substance or reality in material elements in the universe?
Matter and energy constantly change. They are mutable. They could exist as well as not exist. They could have been what they are now as well as they could have been different. It seems there is no substance in matter and energy. There is nothing that exists and persists despite changes in them as the underlying being which sustains their existence.
A Christian could claim that God is exactly this underlying substance who supports, exists independently of, and persists through time changes in material nature. But if there is no God, could we say that there is any substance at all?