If one thing does not differ from any other, it has no identity (it has no properties, features, limits...). If something has no identity, it's not a thing. So only one thing can't exist.
i.e.: I tell you that I have a mysterious object that I call x. The only characteristic of x is that x=x. What is x? I suppose that the only possible answer is "nothing".
Spinoza seems to agree (16 June 1674):
As to the doctrine that figure is negation and not anything positive, it is plain that the whole of matter considered indefinitely can have no figure, and that figure can only exist in finite and determinate bodies. For he who says, that he perceives a figure, merely indicates thereby, that he conceives a determinate thing, and how it is determinate. This determination, therefore, does not appertain to the thing according to its being, but, on the contrary, is its non-being. As then figure is nothing else than determination, and determination is negation, figure, as has been said, can be nothing but negation.
Note: This is not a set theory question, but a metaphysical one. As far as I know, in the set theory the ø avoid the problem through axiomatic means, but I'm not trained in set theory. This question can be probably formulated also as: existence monism coincide with nihilism?